[HTML][HTML] Venoms, venomics, antivenomics

JJ Calvete, L Sanz, Y Angulo, B Lomonte, JM Gutiérrez - FEBS letters, 2009 - Elsevier
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on
vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the …

Snakebite envenoming from a global perspective: Towards an integrated approach

JM Gutiérrez, D Williams, HW Fan, DA Warrell - Toxicon, 2010 - Elsevier
Snakebite envenoming is a neglected public health challenge of compelling importance in
many regions of the world, particularly sub-Saharan Africa, Asia, Latin America and Papua …

Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom

CMA Rego, AF Francisco, CN Boeno, MV Paloschi… - Scientific Reports, 2022 - nature.com
Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake
species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen …

[BOOK][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shop**" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic …

JJ Calvete, L Sanz, P Cid, P de la Torre… - Journal of proteome …, 2010 - ACS Publications
We report a comparative venomic and antivenomic characterization of the venoms of
newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of …

Snake venomics: from the inventory of toxins to biology

JJ Calvete - Toxicon, 2013 - Elsevier
A deep understanding of the composition of venoms and of the principles governing the
evolution of venomous systems is of applied importance for exploring the enormous …

Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus …

J Durban, A Pérez, L Sanz, A Gómez, F Bonilla… - BMC genomics, 2013 - Springer
Background Understanding the processes that drive the evolution of snake venom is a topic
of great research interest in molecular and evolutionary toxinology. Recent studies suggest …

Proteomic tools against the neglected pathology of snake bite envenoming

JJ Calvete - Expert review of proteomics, 2011 - Taylor & Francis
This article covers the application of proteomic tools ('venomics','antivenomics' and 'venom
phenoty**') to study the composition and natural history of snake venoms, and the cross …