Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

Osteoporosis is considered an age-related disorder of the skeletal system, characterized
primarily by decreased bone mineral density (BMD), microstructural quality and an elevated …

Abstract N6-methyladenosine (m6A) is the most abundant epigenetic modification in
eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian …

Aging is associated with progressive changes in total and regional fat distribution that have
negative health consequences. Indeed, a preferential increase in abdominal fat, in particular …

Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …

It is well known that the underlying mechanisms of osteoporosis in older adults are different
than those associated with estrogen deprivation. Age-related bone loss involves a gradual …

Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult
bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function …

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Receptor activator of NF-κB ligand (RANKL) activates, while osteoprotegerin (OPG) inhibits,
osteoclastogenesis. A neutralizing Ab against RANKL, denosumab, improves bone strength …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …