Viral vectors provide an efficient means for modification of eukaryotic cells, and their use is
now commonplace in academic laboratories and industry for both research and clinical …

CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …

The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …

Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse
is a good model system for a young human, and an old mouse, for an elderly human. By …

We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …

Self-renewing cell populations such as hematopoietic stem cells and memory B and T
lymphocytes might be regulated by shared signaling pathways. The Wnt–β-catenin pathway …

The immune system can remember, sometimes for a lifetime, the identity of a pathogen.
Understanding how this is accomplished has fascinated immunologists and microbiologists …

The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive
T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from …

The naïve and memory T lymphocyte pools are maintained through poorly understood
homeostatic mechanisms that may include signaling via cytokine receptors. We show that …

Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also
called KLRK1) expressed by natural killer cells and activated CD8+ T cells, recognize self …