Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives

RN Gacche - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …

Role of VEGF-A and LRG1 in abnormal angiogenesis associated with diabetic nephropathy

A Zhang, H Fang, J Chen, L He, Y Chen - Frontiers in physiology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is an important public health concern of increasing proportions
and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the …

An optimised protocol for platelet-rich plasma preparation to improve its angiogenic and regenerative properties

J Etulain, HA Mena, RP Meiss, G Frechtel, S Gutt… - Scientific reports, 2018 - nature.com
Although platelet-rich plasma (PRP) is used as a source of growth factors in regenerative
medicine, its effectiveness remains controversial, partially due to the absence of PRP …

Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis

MI Zafar, K Mills, X Ye, B Blakely, J Min, W Kong… - Diabetology & metabolic …, 2018 - Springer
Background Several studies have linked vascular endothelial growth factors (VEGFs) with
metabolic syndrome or its components. However, there has been no systematic appraisal of …

Antiangiogenic therapy for diabetic nephropathy

K Tanabe, Y Maeshima, Y Sato… - BioMed research …, 2017 - Wiley Online Library
Angiogenesis has been shown to be a potential therapeutic target for early stages of
diabetic nephropathy in a number of animal experiments. Vascular endothelial growth factor …

Study of the Active Components and Molecular Mechanism of Tripterygium wilfordii in the Treatment of Diabetic Nephropathy

L Wang, Z Wang, Z Yang, K Yang… - Frontiers in Molecular …, 2021 - frontiersin.org
We aimed to explore the active ingredients and molecular mechanism of Tripterygium
wilfordii (TW) in the treatment of diabetic nephropathy (DN) through network pharmacology …

Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease

R Kikuchi, M Stevens, K Harada, S Oltean… - Advances in clinical …, 2019 - Elsevier
Accumulating evidence suggests that pathologic interactions between the heart and the
kidney can contribute to the progressive dysfunction of both organs. Recently, there has …

Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword

QR Tao, YM Chu, L Wei, C Tu… - Molecular Medicine …, 2021 - spandidos-publications.com
Diabetes and the associated complications are becoming a serious global threat and an
increasing burden to human health and the healthcare systems. Diabetic nephropathy (DN) …

[HTML][HTML] Expression of Nrf2 promotes schwann cell-mediated sciatic nerve recovery in diabetic peripheral neuropathy

W Tang, X Chen, H Liu, Q Lv, J Zou, Y Shi… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: High glucose-induced oxidative stress and inflammatory responses play
an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal …

[PDF][PDF] Effects of liraglutide combined with insulin on oxidative stress and serum MCP-1 and NF-κB levels in type 2 diabetes

X Liu, J Huang, J Li, Q Mao, J He - J Coll Physicians Surg Pak, 2019 - jcpsp.pk
Objective: To investigate the effects of liraglutide combined with insulin on oxidative stress
and expression levels of serum monocyte chemoattractant protein-1 (MCP-1) and nuclear …