The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen
through the production of secreted mucus and is fortified by the production of secretory IgA …

Data are accumulating that emphasize the important role of the intestinal barrier and
intestinal permeability for health and disease. However, these terms are poorly defined, their …

Polytrauma (PT) is frequently associated with hemorrhagic shock (HS), which increases
morbidity and mortality. Although various aspects of HS have been addressed in PT …

Intestinal permeability is a key feature of intestinal barrier function. Altered intestinal
permeability is described in many chronic diseases and may be a risk factor for disease …

Increasing evidence suggests that environmental and dietary factors can affect intestinal
epithelial integrity leading to gut permeability and bacterial translocation. Intestinal barrier …

Triacyglycerols are a major energy reserve of the body and are normally stored in adipose
tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested …

Background Early NEC symptoms are non-specific and diagnostic tests lack discriminative
power. Intestinal fatty acid-binding protein (I-FABP), mainly located in small bowel …

An impaired intestinal barrier function can be detrimental to the host as it may allow the
translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In …

Hemorrhagic shock (HS) after tissue trauma increases the complication and mortality rate of
polytrauma (PT) patients. Although several murine trauma models have been introduced …

Background & Aims Gut dysbiosis and inflammation perpetuate loss of gut barrier integrity
(GBI) and pathological bacterial translocation (BT) in cirrhosis, contributing to infection risk …