▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

It is generally assumed that an enzyme-substrate (ES) complex contains all components
necessary for catalysis and that conversion to products occurs by rearrangement of atoms …

Cellular DNA is continually damaged by a plethora of extrinsic and intrinsic sources,
including UV light from the sun and reactive oxygen species resulting from aerobic …

On careful examination of existing kinetic data for correct and incorrect dNTP incorporations
by a variety of DNA polymerases, it is apparent that these enzymes resist a unified …

DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All
polymerases have a common architectural framework consisting of three canonical …

In addition to well-defined DNA repair pathways, all living organisms have evolved
mechanisms to avoid cell death caused by replication fork collapse at a site where …

DNA polymerase η (Pol η) is a eukaryotic lesion bypass polymerase that helps organisms to
survive exposure to ultraviolet (UV) radiation, and tumor cells to gain resistance against …

Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …