An insight on medicinal attributes of pyrimidine scaffold: An updated review
A Vyas, B Sahu, S Pathania, NK Nandi… - Journal of …, 2023 - Wiley Online Library
Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
Pyrazoline derivatives as promising MAO-A targeting antidepressants: an update
Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …
1-Benzhydryl-piperazine: Isolation, structure determination, and in silico studies for a novel potential narcotic agent detected in sports supplements
Adulteration of sports supplements poses significant health risks, necessitating stringent
regulatory oversight. This study investigates deceptive practices by manufacturers, including …
regulatory oversight. This study investigates deceptive practices by manufacturers, including …
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents
Piperazine derivatives have been of great interest to medicinal chemists in the development
of antidepressant drugs due to their distinct molecular and structural features along with their …
of antidepressant drugs due to their distinct molecular and structural features along with their …
Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies
Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably
depression), presenting it as a significant therapeutic target for treating such conditions …
depression), presenting it as a significant therapeutic target for treating such conditions …
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3-nitropropionic acid in in vitro and in vivo models
HM Campos, RM Pereira… - Chemico-Biological …, 2024 - Elsevier
In the pursuit of novel antioxidant therapies for the prevention and treatment of
neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276 …
neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276 …
Nitrogen‐containing heterocyclic compounds: A ray of hope in depression?
Depression is not similar to daily mood fluctuations and temporary emotional responses to
day‐to‐day activities. Depression is not a passing problem; it is an ongoing problem. It deals …
day‐to‐day activities. Depression is not a passing problem; it is an ongoing problem. It deals …
Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4, 5-Dihydrothiazole Ring
G Andreozzi, MR Ambrosio, E Magli, G Maneli… - Pharmaceuticals, 2023 - mdpi.com
Arylpiperazines represent one of the most important classes of 5-HT1AR ligands and have
attracted considerable interests for their versatile properties in chemistry and pharmacology …
attracted considerable interests for their versatile properties in chemistry and pharmacology …