Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be
isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the …

There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM)
worldwide. Uncontrolled T2DM can lead to alterations in the immune system, increasing the …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation
of the synovial lining (synovitis). The inflammation in the RA joint is associated with and …

Recurrent spontaneous abortion affects approximately 1–2% of women of childbearing, and
describes a condition in which women suffer from three or more continuous spontaneous …

Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in
this organ is required to control Mycobacterium tuberculosis growth, but this can also result …

Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F,
tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related …

Cytokines play a pivotal role in the pathogenesis of autoimmune diseases. The precise
triggers for the breakdown of self-tolerance and the subsequent events leading to the …

Abstract OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON Th17 CELLS
Induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2009; doi …

Abstract CD4+ CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with
immunosuppressive functions that play a critical role in maintaining immune homeostasis …

A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …