Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder

M Fitzpatrick, LC Solberg Woods - Physiological Genomics, 2024‏ - journals.physiology.org
Obesity and major depressive disorder (MDD) are both significant health issues that have
been increasing in prevalence and are associated with multiple comorbidities. Obesity and …

[HTML][HTML] Activation of 5-HT1A receptors normalizes the overexpression of presynaptic 5-HT1A receptors and alleviates diabetic neuropathic pain

N Munawar, MS Bitar, W Masocha - International Journal of Molecular …, 2023‏ - mdpi.com
Neuropathic pain is a well-documented phenomenon in experimental and clinical diabetes;
however, current treatment is unsatisfactory. Serotoninergic-containing neurons are key …

[HTML][HTML] Dectin-1 as a potential inflammatory biomarker for metabolic inflammation in adipose tissue of individuals with obesity

A Al Madhoun, S Kochumon, F Al-Rashed, S Sindhu… - Cells, 2022‏ - mdpi.com
In obesity, macrophage activation and infiltration in adipose tissue (AT) underlie chronic low-
grade inflammation-induced insulin resistance. Although dectin-1 is primarily a pathogen …

[HTML][HTML] Metformin's mechanism of action is stimulation of the biosynthesis of the natural cyclic AMP antagonist prostaglandylinositol cyclic phosphate (cyclic PIP)

HK Wasner - International Journal of Molecular Sciences, 2022‏ - mdpi.com
Metformin is the leading drug for treating type 2 diabetics, but the mechanism of action of
metformin, despite some suggested mechanisms such as the activation of the AMP-kinase …

Metabolomics and lipidomics signatures of insulin resistance and abdominal fat depots in people living with obesity

YC Koay, ACF Coster, DL Chen, B Milner, A Batarseh… - Metabolites, 2022‏ - mdpi.com
The liver, skeletal muscle, and adipose tissue are major insulin target tissues and key
players in glucose homeostasis. We and others have described diverse insulin resistance …

CRTC3 regulates the lipid metabolism and adipogenic differentiation of porcine intramuscular and subcutaneous adipocytes by activating the calcium pathway

J Liu, L Wang, W Chen, J Li, T Shan - Journal of Agricultural and …, 2021‏ - ACS Publications
Fat deposition, especially the intramuscular (IM) fat deposition, is directly associated with
meat quality. The cyclic adenosine monophosphate (cAMP)-responsive element binding …

Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health

IA Durrani, A Bhatti, P John - PLoS One, 2023‏ - journals.plos.org
The bidirectional causal relationship between type 2 diabetes mellitus (T2DM) and breast
cancer (BC) has been established by numerous epidemiological studies. However, the …

Transcriptome profiling based on protein–protein interaction networks provides a set of core genes for understanding the immune response mechanisms of the egg …

Z Li, X Bao, X Liu, Y Li, M Cui, X Liu, B Li, Y Feng… - Fish & Shellfish …, 2021‏ - Elsevier
Protection via of the immune system is indispensable to the life of organisms. Within an
immune network, problems with a given link will affect the normal life activities of the …

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells

SH Lee, V Veeriah, F Levine - PloS one, 2022‏ - journals.plos.org
HNF4α has been implicated in IBD through a number of genome-wide association studies.
Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT) …

[HTML][HTML] Plasma exosomal miRNA levels after radiotherapy are associated with early progression and metastasis of cervical cancer: a pilot study

O Cho, DW Kim, JY Cheong - Journal of Clinical Medicine, 2021‏ - mdpi.com
Plasma exosomal miRNAs are key regulators of cell-cell interactions associated with several
biological functions in patients with cancer. This pilot study aimed to investigate the log2 fold …