Gibberellic Acid (GA3): A Versatile Chiral Building Block for Syntheses of Pharmaceutical Agents

Z Alabdeen Khdar, TM Le… - Chemistry & Biodiversity, 2025 - Wiley Online Library
Abstract Gibberellic acid (GA3), an ent‐kaurene tetracyclic diterpene, has been considered
to be a chiral pool for the chemical transformation of significant heterocyclic compounds …

SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections

MA Khanfar, MI Saleh - Current Medicinal Chemistry, 2025 - benthamdirect.com
Background The main protease (Mpro) is a crucial enzyme for the life cycle of SARS-CoV-2
and a validated target for the treatment of COVID-19 infection. Natural products have been a …

Halosulfonamidation of camphene: chemo and stereoselectivity, rearrangement, solvent interception, heterocyclization

MY Moskalik, IA Garagan, BA Shainyan… - New Journal of …, 2024 - pubs.rsc.org
The first study on oxidative sulfonamidation of camphene is presented. By varying the
reaction conditions, the nature of the sulfonamide, the oxidizing agent, the ratio of the …

Engineering Escherichia coli via introduction of the isopentenol utilization pathway to effectively produce geranyllinalool

J Chang, X Wei, D Liu, Q Li, C Li, J Zhao, L Cheng… - Microbial Cell …, 2024 - Springer
Background Geranyllinalool, a natural diterpenoid found in plants, has a floral and woody
aroma, making it valuable in flavors and fragrances. Currently, its synthesis primarily …

Ring-reorganization strategy for asymmetric synthesis of sesquiterpenoid illihenin A and its antiviral activity evaluation

WR Li, RB Wang, H Wang, JY Yong, YH Li, SS Yu… - Chinese Chemical …, 2025 - Elsevier
Herein, we report the first asymmetric synthesis of illihenin A, an antiviral sesquiterpenoid
bearing a cage-like tricyclo [6.2. 2.0 1, 5] dodecane skeleton. Starting from an abundant …

Potent antiviral action detected in Tontelea micrantha extracts against Alphavirus chikungunya

RP Lopes, MA Máximo Vaz, FL Ferreira… - Drug Development …, 2025 - Taylor & Francis
Background Tontelea micrantha, a notable plant species, has garnered interest for its
medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A …

Biomimetic chemical reactions with natural products using metalloporphyrins and salen complexes as catalysts: a brief review

RCN Sousa, VPP Confessor… - Chemistry & …, 2024 - Wiley Online Library
The cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are
versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various …

An Introduction to Specialized Metabolites from Plants, Their Biological and Ecological Roles, and Biotechnological Interventions to Improve the Production

KG Ramawat, JM Mèrillon - Plant Specialized Metabolites: Phytochemistry …, 2023 - Springer
Plants obtain their energy-producing carbohydrates from photosynthesis, which in turn are
diverted into various primary and secondary metabolites. Plant secondary metabolites are …

Herbal Medicines: From History to Current Research—A Comprehensive Survey

ACJ Silva, AV Fassio, MP Barcelos… - Progress in Hydrogen …, 2024 - Springer
The use of natural resources, particularly plants, for prophylactic and curative purposes
dates back to ancient times and has been employed by various indigenous peoples. To …

Total Synthesis of Prezizane-type Sesquiterpenes

NJ Rauscher - 2024 - mediatum.ub.tum.de
A photochemical cascade reaction was utilized as key step for the total synthesis of the
prezizane-type sesquiterpenes agarozizanol B, **kohol II, and **koholic acid. Agarozizanol …