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Gibberellic Acid (GA3): A Versatile Chiral Building Block for Syntheses of Pharmaceutical Agents
Z Alabdeen Khdar, TM Le… - Chemistry & Biodiversity, 2025 - Wiley Online Library
Abstract Gibberellic acid (GA3), an ent‐kaurene tetracyclic diterpene, has been considered
to be a chiral pool for the chemical transformation of significant heterocyclic compounds …
to be a chiral pool for the chemical transformation of significant heterocyclic compounds …
SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections
MA Khanfar, MI Saleh - Current Medicinal Chemistry, 2025 - benthamdirect.com
Background The main protease (Mpro) is a crucial enzyme for the life cycle of SARS-CoV-2
and a validated target for the treatment of COVID-19 infection. Natural products have been a …
and a validated target for the treatment of COVID-19 infection. Natural products have been a …
Halosulfonamidation of camphene: chemo and stereoselectivity, rearrangement, solvent interception, heterocyclization
MY Moskalik, IA Garagan, BA Shainyan… - New Journal of …, 2024 - pubs.rsc.org
The first study on oxidative sulfonamidation of camphene is presented. By varying the
reaction conditions, the nature of the sulfonamide, the oxidizing agent, the ratio of the …
reaction conditions, the nature of the sulfonamide, the oxidizing agent, the ratio of the …
Engineering Escherichia coli via introduction of the isopentenol utilization pathway to effectively produce geranyllinalool
J Chang, X Wei, D Liu, Q Li, C Li, J Zhao, L Cheng… - Microbial Cell …, 2024 - Springer
Background Geranyllinalool, a natural diterpenoid found in plants, has a floral and woody
aroma, making it valuable in flavors and fragrances. Currently, its synthesis primarily …
aroma, making it valuable in flavors and fragrances. Currently, its synthesis primarily …
Ring-reorganization strategy for asymmetric synthesis of sesquiterpenoid illihenin A and its antiviral activity evaluation
WR Li, RB Wang, H Wang, JY Yong, YH Li, SS Yu… - Chinese Chemical …, 2025 - Elsevier
Herein, we report the first asymmetric synthesis of illihenin A, an antiviral sesquiterpenoid
bearing a cage-like tricyclo [6.2. 2.0 1, 5] dodecane skeleton. Starting from an abundant …
bearing a cage-like tricyclo [6.2. 2.0 1, 5] dodecane skeleton. Starting from an abundant …
Potent antiviral action detected in Tontelea micrantha extracts against Alphavirus chikungunya
RP Lopes, MA Máximo Vaz, FL Ferreira… - Drug Development …, 2025 - Taylor & Francis
Background Tontelea micrantha, a notable plant species, has garnered interest for its
medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A …
medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A …
Biomimetic chemical reactions with natural products using metalloporphyrins and salen complexes as catalysts: a brief review
RCN Sousa, VPP Confessor… - Chemistry & …, 2024 - Wiley Online Library
The cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are
versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various …
versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various …
An Introduction to Specialized Metabolites from Plants, Their Biological and Ecological Roles, and Biotechnological Interventions to Improve the Production
KG Ramawat, JM Mèrillon - Plant Specialized Metabolites: Phytochemistry …, 2023 - Springer
Plants obtain their energy-producing carbohydrates from photosynthesis, which in turn are
diverted into various primary and secondary metabolites. Plant secondary metabolites are …
diverted into various primary and secondary metabolites. Plant secondary metabolites are …
Herbal Medicines: From History to Current Research—A Comprehensive Survey
The use of natural resources, particularly plants, for prophylactic and curative purposes
dates back to ancient times and has been employed by various indigenous peoples. To …
dates back to ancient times and has been employed by various indigenous peoples. To …
Total Synthesis of Prezizane-type Sesquiterpenes
NJ Rauscher - 2024 - mediatum.ub.tum.de
A photochemical cascade reaction was utilized as key step for the total synthesis of the
prezizane-type sesquiterpenes agarozizanol B, **kohol II, and **koholic acid. Agarozizanol …
prezizane-type sesquiterpenes agarozizanol B, **kohol II, and **koholic acid. Agarozizanol …