New growth in the vascular network is important since the proliferation, as well as metastatic
spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the …

Increased vascular endothelial growth factor (VEGF) levels are associated with osteoarthritis
(OA) progression. Indeed, VEGF appears to be involved in OA‐specific pathologies …

Wound healing is a complex event that develops in three overlap** phases: inflammatory,
proliferative, and remodeling. These phases are distinct in function and histological …

Abstract Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that
limits vessel density in normal tissues and curtails tumor growth. Here, we show that the …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of …

Conventional views of the tunica adventitia as a poorly organized layer of vessel wall
composed of fibroblasts, connective tissue, and perivascular nerves are undergoing …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

Vasculogenesis and angiogenesis are the fundamental processes by which new blood
vessels are formed (Carmeliet, 2000; Risau, 1997; Risau and Flamme, 1995) …

Apoptotic death has now been recognized in a number of common and threatening vascular
diseases, including atherosclerosis. Interest in apoptosis research relates to the fact that …