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Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Nanoenabled intracellular metal ion homeostasis regulation for tumor therapy
L Xu, M Peng, T Gao, D Wang, X Lian, H Sun… - Advanced …, 2024 - Wiley Online Library
Endogenous essential metal ions play an important role in many life processes, especially in
tumor development and immune response. The approval of various metallodrugs for tumor …
tumor development and immune response. The approval of various metallodrugs for tumor …
A vacancy‐engineering ferroelectric nanomedicine for cuproptosis/apoptosis co‐activated immunotherapy
Low efficacy of immunotherapy due to the poor immunogenicity of most tumors and their
insufficient infiltration by immune cells highlights the importance of inducing immunogenic …
insufficient infiltration by immune cells highlights the importance of inducing immunogenic …
Zinc–iron bimetallic peroxides modulate the tumor stromal microenvironment and enhance cell immunogenicity for enhanced breast cancer immunotherapy therapy
Immunotherapy has emerged as a potential approach for breast cancer treatment. However,
the rigid stromal microenvironment and low immunogenicity of breast tumors strongly reduce …
the rigid stromal microenvironment and low immunogenicity of breast tumors strongly reduce …
Lysosomal rupture‐mediated “broken window effect” to amplify cuproptosis and pyroptosis for high‐efficiency cancer immunotherapy
G Zhu, M Wang, L Qiao, Y **e, J Wang… - Advanced Functional …, 2024 - Wiley Online Library
Autophagy, a lysosome‐involved degradation pathway, as a self‐protective cellular process,
always weakens the efficiency of tumor therapies. Herein, for the first time, the …
always weakens the efficiency of tumor therapies. Herein, for the first time, the …
Liquid nanoparticles for nanocatalytic cancer therapy
Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐
involved cancer‐therapeutic modality, which unfortunately suffers from undesirable …
involved cancer‐therapeutic modality, which unfortunately suffers from undesirable …
Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines
Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …
Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections
Pathogen-host competition for manganese and intricate immunostimulatory pathways
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …
Revealing the mutually enhanced mechanism of necroptosis and immunotherapy induced by defect engineering and piezoelectric effect
Y Du, J Yang, F He, X Zhao, J Zhou, P Zang… - Advanced …, 2024 - Wiley Online Library
Owing to low immunogenicity‐induced immune escape and short‐term circulating immune
responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering …
responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering …
cGAS-STING signaling in the tumor microenvironment
The cGAS-STING signaling is an important pathway involved in the regulation of tumor
microenvironment, which affects many cellular functions including immune activation. Its role …
microenvironment, which affects many cellular functions including immune activation. Its role …