Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle soon after birth in
mammals. Although the extent to which adult cardiac myocytes are capable of cell cycle …

Abstract Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions
and phenomena, including cell proliferation, differentiation, survival, adhesion, migration …

The effects of growth factors on tissue remodeling and cell differentiation depend on the
nature of the extracellular matrix, the type and organization of integrins, the activation of …

In vitro, fibroblast growth factor-2 (FGF2) has been implicated in cardiomyocyte growth and
reexpression of fetal contractile genes, both markers of hypertrophy. However, its in vivo role …

Tissue engineering has become a primary research topic for the treatment of diseased or
damaged cardiac tissue, which is a global healthcare concern. Current tissue engineering …

FGF-2 has been implicated in the cardiac response to hypertrophic stimuli. Angiotensin II
(Ang II) contributes to maintain elevated blood pressure in hypertensive individuals and …

Regulation of organ growth is critical during embryogenesis. At the cellular level,
mechanisms controlling the size of individual embryonic organs include cell proliferation …

Cardiac hypertrophy and fibrosis are two closely related adaptive response mechanisms of
the myocardium to mechanical, metabolic, and genetic stress that finally contribute to the …

Abstract Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell
growth and differentiation and becomes upregulated by stress, is expressed as AUG …

Pericardial fluid (PF) may contain myocardial growth factors that exert paracrine actions on
cardiac myocytes. The aims of this study were (1) to investigate the effects of human PF and …