The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Cell proliferation is central to epithelial tissue development, repair, and homeostasis. During
cell division, small RhoGTPases control both actomyosin dynamics and cell-cell junction …

Stem cells are fundamental units of tissue remodeling whose functions are dictated by
lineage-specific transcription factors. Home to epidermal stem cells and their upward …

Simple Summary Skin cancer is the most common cancer in human. Melanoma, basal cell
carcinoma and squamous cell carcinoma are the most prevalent skin cancer subtypes. A …

Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however,
the mechanisms that orchestrate the cell shape and packing dynamics required to establish …

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is member of the IQGAP family of
scaffold proteins, which are essential for assembling multiprotein complexes that coordinate …

Since their discovery, Rho GTPases have emerged as key regulators of cytoskeletal
dynamics. In humans, there are 20 Rho GTPases and more than 150 regulators that belong …

Background The establishment of tissue architecture requires coordination between distinct
processes including basement membrane assembly, cell adhesion, and polarity; however …

BACKGROUND RhoA GTPase plays critical roles in actin cytoskeletal remodeling required
for controlling a diverse range of cellular functions including cell proliferation, cell …

During embryogenesis, cells arrange into precise patterns that enable tissues and organs to
develop specialized functions. Despite its critical importance, the molecular choreography …