Investigation of wall shear stress in cardiovascular research and in clinical practice—from bench to bedside
K Urschel, M Tauchi, S Achenbach, B Dietel - International Journal of …, 2021 - mdpi.com
In the 1900s, researchers established animal models experimentally to induce
atherosclerosis by feeding them with a cholesterol-rich diet. It is now accepted that high …
atherosclerosis by feeding them with a cholesterol-rich diet. It is now accepted that high …
[HTML][HTML] In vitro fluidic systems: Applying shear stress on endothelial cells
F Meng, H Cheng, J Qian, X Dai, Y Huang… - Medicine in Novel …, 2022 - Elsevier
Endothelial cells (ECs) that reside on the surface of blood vessels are constantly exposed to
mechanical stimulation, including shear stress. Fluid shear stress (FSS) controls multiple …
mechanical stimulation, including shear stress. Fluid shear stress (FSS) controls multiple …
[HTML][HTML] Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method
A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial
tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) …
tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) …
[HTML][HTML] Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro
One of the major aims of bio-engineering tissue equivalents in vitro is to create
physiologically relevant culture conditions to accurately recreate the cellular …
physiologically relevant culture conditions to accurately recreate the cellular …
Biomechanical determinants of endothelial permeability assessed in standard and modified hollow-fibre bioreactors
Effects of mechanical stress on the permeability of vascular endothelium are important to
normal physiology and in the development of atherosclerosis. Here we elucidate novel …
normal physiology and in the development of atherosclerosis. Here we elucidate novel …
Detection of frequency-dependent endothelial response to oscillatory shear stress using a microfluidic transcellular monitor
The endothelial microenvironment is critical in maintaining the health and function of the
intimal layer in vasculature. In the context of cardiovascular disease (CVD), the vascular …
intimal layer in vasculature. In the context of cardiovascular disease (CVD), the vascular …
A microfluidic impedance platform for real-time, in vitro characterization of endothelial cells undergoing fluid shear stress
We introduce a microfluidic impedance platform to electrically monitor in real-time,
endothelium monolayers undergoing fluid shear stress. Our platform incorporates sensing …
endothelium monolayers undergoing fluid shear stress. Our platform incorporates sensing …
Endothelial‐Smooth Muscle Cell Interactions in a Shear‐Exposed Intimal Hyperplasia on‐a‐Dish Model to Evaluate Therapeutic Strategies
A Fernandes, A Miéville, F Grob, T Yamashita… - Advanced …, 2022 - Wiley Online Library
Intimal hyperplasia (IH) represents a major challenge following cardiovascular interventions.
While mechanisms are poorly understood, the inefficient preventive methods incentivize the …
While mechanisms are poorly understood, the inefficient preventive methods incentivize the …
Orbitally shaken shallow fluid layers. I. Regime classification
Orbital shakers are simple devices that provide mixing, aeration, and shear stress at multiple
scales and high throughput. For this reason, they are extensively used in a wide range of …
scales and high throughput. For this reason, they are extensively used in a wide range of …
Personalized drug efficacy monitoring chip
Cancer drug resistance mechanisms such as tumor heterogeneity and adaptable feedback
loops are prevalent issues facing cancer therapy development. Drug resistance can be …
loops are prevalent issues facing cancer therapy development. Drug resistance can be …