Immunosuppressive mechanisms of regulatory B cells

D Catalán, MA Mansilla, A Ferrier, L Soto… - Frontiers in …, 2021 - frontiersin.org
Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

CD4+ T cell activation and inflammation in NASH-related fibrosis

Y Zhou, H Zhang, Y Yao, X Zhang, Y Guan… - Frontiers in …, 2022 - frontiersin.org
Liver fibrosis is a common pathological feature of end stage liver failure, a severe life-
threatening disease worldwide. Nonalcoholic fatty liver disease (NAFLD), especially its more …

The differential roles of T cells in non-alcoholic fatty liver disease and obesity

MA Van Herck, J Weyler, WJ Kwanten… - Frontiers in …, 2019 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) constitutes a spectrum of disease states
characterized by hepatic steatosis and is closely associated to obesity and the metabolic …

Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy

G Tarantino, V Citro, D Capone - Journal of clinical medicine, 2020 - mdpi.com
Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD),
their uncertainty does not always permit a clear elucidation of the grassroot alterations that …

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review

Y Liu, J Wang, S Luo, Y Zhan, Q Lu - Journal of Autoimmunity, 2020 - Elsevier
Autoimmune diseases are common diseases of the immune system that are characterized
by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune …

Regulatory T cell: A double-edged sword from metabolic-dysfunction-associated steatohepatitis to hepatocellular carcinoma

H Wang, A Tsung, L Mishra, H Huang - EBioMedicine, 2024 - thelancet.com
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming a leading
cause of end-stage liver disease globally. Metabolic-dysfunction-associated steatohepatitis …

[HTML][HTML] Altered lipid metabolism in blood mononuclear cells of psoriatic patients indicates differential changes in psoriasis vulgaris and psoriatic arthritis

P Wójcik, M Biernacki, A Wroński, W Łuczaj… - International journal of …, 2019 - mdpi.com
The aim of this study was to investigate possible stress-associated disturbances in lipid
metabolism in mononuclear cells, mainly lymphocytes of patients with psoriasis vulgaris (Ps …

The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy

A Hasankhani, A Bahrami, B Tavakoli-Far… - Frontiers in …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower …

Roles of PPAR activation in cancer therapeutic resistance: Implications for combination therapy and drug development

Y Zhang, B **ao, Y Liu, S Wu, Q **ang, Y **ao… - European Journal of …, 2024 - Elsevier
Therapeutic resistance is a major obstacle to successful treatment or effective containment
of cancer. Peroxisome proliferator-activated receptors (PPARs) play an essential role in …

Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy

Y Shan, T **e, Y Sun, Z Lu, W Topatana… - Biomarker …, 2024 - Springer
Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as
they avoid excessive inflammation and mediate tumor development. The abundance of …