THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in …

Insulin and leptin are hypothesized to beadiposity signals' for the long-term regulation of
body weight by the brain. Accordingly, a change in the plasma levels of leptin or insulin …

Obesity represents one of the most serious global health issues with∼ 310 million people
presently affected. It develops because of a mismatch between energy intake and …

This review article discusses the well-established role of the dorsomedial hypothalamic
nucleus (DMN) in feeding, drinking and body weight (BW) regulation. DMN lesions (L) in …

Oxytocin neurons have a physiological role in food intake and energy balance. Central
administration of oxytocin is powerfully anorexigenic, reducing food intake and meal …

In mammals, the orexigenic and anorexigenic neuronal systems are morphologically and
functionally connected, forming an interconnected network in the hypothalamus to govern …

Neuropeptide Y is the most potent physiological appetite transducer known. The NPY
network is the conductor of the hypothalamic appetite regulating orchestra in the arcuate …

Leptin is involved in the hypothalamic control of food intake and body weight. Fos
immunohistochemistry has been used to functionally map leptin target neurons involved in …