Rapid progress in tissue engineering research in past decades has opened up vast
possibilities to tackle the challenges of generating tissues or organs that mimic native …

Microengineering advances have enabled the development of perfusable, endothelialized
models of the microvasculature that recapitulate the unique biological and biophysical …

The vascular endothelium presents a major transport barrier to drug delivery by only
allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug …

Efforts to create platelet-like structures for the augmentation of haemostasis have focused
solely on recapitulating aspects of platelet adhesion; more complex platelet behaviours such …

The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2
infection remains poorly understood. Endothelial damage and microvascular thrombosis …

Despite its revolutionary success in hematological malignancies, chimeric antigen receptor
T (CAR‐T) cell therapy faces disappointing clinical results in solid tumors. The poor efficacy …

Investigating biophysical cellular interactions in the circulation currently requires choosing
between in vivo models, which are difficult to interpret due in part to the hemodynamic and …

Hemostasis encompasses an ensemble of interactions among platelets, coagulation factors,
blood cells, endothelium, and hemodynamic forces, but current assays assess only isolated …

Leukocytes normally marginate toward the vascular wall in large vessels and within the
microvasculature. Reversal of this process, leukocyte demargination, leads to substantial …

Abstract Microvasculatures-on-a-chip, ie in vitro models that mimic important features of
microvessel networks, have gained increasing interest in recent years. Such devices have …