Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Diseases of the central nervous system (CNS) are often associated with vascular
disturbances or inflammation and frequently both. Consequently, endothelial cells and …

Objective Because the role of white matter (WM) degenerating microglia (DM) in
remyelination failure is unclear, we sought to define the core features of this novel …

This study was focused on exploring the role of the HIV-1 Tat protein in mediating microglial
ferroptosis. Exposure of mouse primary microglial cells (mPMs) to HIV-1 Tat protein resulted …

Growing evidence has implicated systemic infection as a significant risk factor for the
development and advancement of Alzheimer's disease (AD). With the emergence of SARS …

Heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), cobalt (Co), copper (Cu),
manganese (Mn), zinc (Zn), and others, have a significant impact on the development and …

Abstract Alzheimer's disease (AD), the most common type of dementia in the elderly, is a
chronic and progressive neurodegenerative disorder with no effective disease-modifying …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder
characterized by the aggregation of α-Synuclein (αSYN) building up intraneuronal …

Microglia may only represent 10% of central nervous system (CNS) cells but they perform
critical roles in development, homeostasis and neurological disease. Microglia are also …

Hemoglobin and iron overload is considered the major contributor to intracerebral
hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia …