Simple Summary Xenopus laevis is an anuran amphibian that has been used for decades
as the principal vertebrate model to study embryonic development. Among the advantages …

ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT
inflammation. The control of the ATM number may have therapeutic potential; however …

Initially intended for nutrient uptake, phagocytosis represents a central mechanism of debris
removal and host defense against invading pathogens through the entire animal kingdom. In …

Macrophage (M ϕ)-lineage cells are integral to the immune defences of all vertebrates,
including amphibians. Across vertebrates, M ϕ differentiation and functionality depend on …

The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian
inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8 …

In the present study, using transgenic frogs that express GFP specifically in myeloid cells
under the myeloperoxidase enhancer sequence, we found that myeloperoxidase-positive …

Granulocyte-lineage cells are important innate immune effectors across all vertebrates.
Named for conspicuous secretory granules, granulocytes have historically been studied for …

Across vertebrates, hematopoiesis takes place within designated tissues, wherein
committed myeloid progenitors further differentiate toward cells with megakaryocyte …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the
leading global cause of death from an infectious agent. Mycobacteria thrive within their host …

Granulocyte colony-stimulating factor (GCSF) is a member of the hematopoietic growth
factor family that acts primarily on neutrophils and neutrophilic precursors to promote cell …