Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …

The Wilderness Medical Society convened an expert panel to develop a set of evidence-
based guidelines for prevention and treatment of frostbite. We present a review of pertinent …

Production of thromboxane (TX) A2 and PG I2/prostacyclin (PGI2) is increased in patients
with atherosclerosis. However, their roles in atherogenesis have not been critically defined …

Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in
atherosclerosis and is classically defined as a switch from a 'contractile'phenotype to a …

Objective Digital ulcerations are one of the most frequent manifestations of microangiopathy
in patients with systemic sclerosis (SSc; scleroderma). The early detection of SSc patients …

Tumours have at least two mechanisms that can alter dendritic cell (DC) maturation and
function. The first affects the ability of haematopoietic progenitors to differentiate into …

Prostacyclin (PGI2) is a member of the prostaglandin family of bioactive lipids. Its best-
characterized role is in the cardiovascular system, where it is released by vascular …

The spectrum of scleroderma spans Raynaud's phenomenon, localized forms of skin fibrosis
and the clinically most important forms of systemic sclerosis that involve inflammatory …

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …