Roadmap for precision preclinical x-ray radiation studies

F Verhaegen, KT Butterworth… - Physics in Medicine …, 2023 - iopscience.iop.org
This Roadmap paper covers the field of precision preclinical x-ray radiation studies in
animal models. It is mostly focused on models for cancer and normal tissue response to …

[HTML][HTML] Quantitative bioluminescence tomography-guided conformal irradiation for preclinical radiation research

X Xu, Z Deng, H Dehghani, I Iordachita, M Lim… - International Journal of …, 2021 - Elsevier
Purpose Widely used cone beam computed tomography (CBCT)-guided irradiators in
preclinical radiation research are limited to localize soft tissue target because of low imaging …

Small animal IMRT using 3D-printed compensators

G Redler, E Pearson, X Liu, I Gertsenshteyn… - International Journal of …, 2021 - Elsevier
Purpose Preclinical radiation replicating clinical intensity modulated radiation therapy
(IMRT) techniques can provide data translatable to clinical practice. For this work, treatment …

Feasibility of a novel sparse orthogonal collimator–based preclinical total marrow irradiation for enhanced dosimetric conformality

AMH Abdelhamid, L Jiang, D Zuro, A Liu… - Frontiers in …, 2022 - frontiersin.org
Total marrow irradiation (TMI) has significantly improved radiation conditioning for
hematopoietic cell transplantation in hematologic diseases by reducing conditioning …

Multi‐MATE, a high‐throughput platform for automated image‐guided small‐animal irradiation

L Jiang, P Ramesh, R Neph, K Sheng - Medical physics, 2023 - Wiley Online Library
Background Small animal irradiation is essential to study the radiation response of new
interventions before or parallel to human therapy. Image‐guided radiotherapy (IGRT) and …

Characterization of Inorganic Scintillator Detectors for Dosimetry in Image-Guided Small Animal Radiotherapy Platforms

I Silvestre Patallo, A Subiel, R Carter, S Flynn… - Cancers, 2023 - mdpi.com
The purpose of the study was to characterize a detection system based on inorganic
scintillators and determine its suitability for dosimetry in preclinical radiation research. Dose …

[HTML][HTML] Robust Automated Mouse Micro-CT Segmentation Using Swin UNEt TRansformers

L Jiang, D Xu, Q Xu, A Chatziioannou, KS Iwamoto… - Bioengineering, 2024 - mdpi.com
Image-guided mouse irradiation is essential to understand interventions involving radiation
prior to human studies. Our objective is to employ Swin UNEt TRansformers (Swin UNETR) …

An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation

L Jiang, Q Lyu, AMH Abdelhamid, S Hui… - Physics in Medicine & …, 2022 - iopscience.iop.org
Objective. Intensity-modulated radiotherapy (IMRT) is widely used in clinical radiotherapy,
treating varying malignancies with conformal doses. As the test field for clinical translation …

Improving the efficiency of small animal 3D‐printed compensator IMRT with beamlet intensity total variation regularization

X Liu, AL Van Slyke, E Pearson, K Shoniyozov… - Medical …, 2022 - Wiley Online Library
Purpose There is growing interest in the use of modern 3D printing technology to implement
intensity‐modulated radiation therapy (IMRT) on the preclinical scale that is analogous to …

Anatomy-constrained synthesis for spleen segmentation improvement in unpaired mouse micro-CT scans with 3D CycleGAN

L Jiang, D Xu, K Sheng - Biomedical Physics & Engineering …, 2024 - iopscience.iop.org
Objective. Auto-segmentation in mouse micro-CT enhances the efficiency and consistency
of preclinical experiments but often struggles with low-native-contrast and morphologically …