Mechanisms of bone development and repair
A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
SOX9 and the many facets of its regulation in the chondrocyte lineage
V Lefebvre, M Dvir-Ginzberg - Connective tissue research, 2017 - Taylor & Francis
ABSTRACT SOX9 is a pivotal transcription factor in develo** and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …
is expressed from the multipotent skeletal progenitor stage and is active throughout …
Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation
Cartilage is essential throughout vertebrate life. It starts develo** in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis
CF Liu, V Lefebvre - Nucleic acids research, 2015 - academic.oup.com
SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are
closely related DNA-binding proteins that critically enhance its function. We use here …
closely related DNA-binding proteins that critically enhance its function. We use here …
SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …
Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
SOX9 plays an important role in chondrocyte differentiation and, in the develo** axial
skeleton, maintains the notochord and the demarcation of intervertebral disc compartments …
skeleton, maintains the notochord and the demarcation of intervertebral disc compartments …
Adolescent idiopathic scoliosis: a review of aetiological theories of a multifactorial disease
S Marya, AD Tambe, PA Millner… - The bone & joint …, 2022 - boneandjoint.org.uk
Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …