Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

ABSTRACT SOX9 is a pivotal transcription factor in develo** and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …

Cartilage is essential throughout vertebrate life. It starts develo** in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …

Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …

SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are
closely related DNA-binding proteins that critically enhance its function. We use here …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …

Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …