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Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
Mitral valve disease—morphology and mechanisms
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
Mechanical regulation of cardiac development
Mechanical forces are essential contributors to and unavoidable components of cardiac
formation, both inducing and orchestrating local and global molecular and cellular changes …
formation, both inducing and orchestrating local and global molecular and cellular changes …
Potential drug targets for calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …
mortality and, given its association with age, the prevalence of CAVD is expected to continue …
Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells
Understanding the role of mechanical forces on cell behavior is critical for tissue
engineering, regenerative medicine, and disease initiation studies. Current hemodynamic …
engineering, regenerative medicine, and disease initiation studies. Current hemodynamic …
Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype
Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however,
persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To …
persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To …
Hemodynamic and cellular response feedback in calcific aortic valve disease
This review highlights aspects of calcific aortic valve disease that encompass the entire
range of aortic valve disease progression from initial cellular changes to aortic valve …
range of aortic valve disease progression from initial cellular changes to aortic valve …
Development of calcific aortic valve disease: do we know enough for new clinical trials?
Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …
[HTML][HTML] Oxidative stress and valvular endothelial cells in aortic valve calcification
Calcified aortic valve disease (CAVD) is a common cardiovascular disease in elderly
individuals. Although it was previously considered a degenerative disease, it is, in fact, a …
individuals. Although it was previously considered a degenerative disease, it is, in fact, a …