In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered
when an organ undergoes a transient reduction or cessation of blood flow, followed by re …

Necroptosis is considered to be complementary to the classical caspase-dependent
programmed cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Necroptotic cell death is mediated by the most terminal known effector of the pathway,
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …

Necroptosis is mediated by a signaling complex called necrosome, containing receptor-
interacting protein (RIP) 1, RIP3, and mixed-lineage kinase domain-like (MLKL). It is known …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …

Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl
transfer, termed pseudokinases, have emerged as important signalling domains across all …