Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the
National Human Genome Research Institute to sequence thousands of tumors representing …

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of
tumor development. Because their expression is exclusive to cancer cells and their …

The post-genomic era has seen many advances inBaryza and G. Rice for helpful our
understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate …

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS).
However, the epigenetic networks underlying the maintenance of oncogenic signaling and …

Background Compared with adult cancers, pediatric cancers are uniquely characterized by
a genomically stable landscape and lower tumor mutational burden. Alternative splicing …

Purpose: The importance of cellular context to the synergy of DNA damage response (DDR)-
targeted agents is important for tumors with mutations in DDR pathways, but less well …

In the presence of physiological monovalent cations, thousands of RNA G-rich sequences
can form parallel G-quadruplexes (G4s) unless RNA-binding proteins inhibit, destabilize, or …

Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …