[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …
NAD+ and sirtuins in aging and disease
S Imai, L Guarente - Trends in cell biology, 2014 - cell.com
Nicotinamide adenine dinucleotide (NAD+) is a classical coenzyme mediating many redox
reactions. NAD+ also plays an important role in the regulation of NAD+-consuming …
reactions. NAD+ also plays an important role in the regulation of NAD+-consuming …
Brain metabolism in health, aging, and neurodegeneration
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …
activity in neuronal circuits, and from environmental energetic stressors such as food …
Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …
cellular sensors to detect energy availability and modulate metabolic processes. Two …
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
FOXO transcription factors as therapeutic targets in human diseases
Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
[HTML][HTML] SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
HC Chang, L Guarente - Cell, 2013 - cell.com
SIRT1 is a NAD+-dependent protein deacetylase that governs many physiological
pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the …
pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the …
SIRT1 in neurodevelopment and brain senescence
AZ Herskovits, L Guarente - Neuron, 2014 - cell.com
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …
traditionally been linked with calorie restriction and aging in mammals. These proteins also …
Calorie restriction and sirtuins revisited
L Guarente - Genes & development, 2013 - genesdev.cshlp.org
Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most
robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins …
robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins …