Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

Most animals require sleep, and sleep loss induces serious pathophysiological
consequences, including death. Previous experimental approaches for investigating sleep …

The metabolic signals that regulate sleep and the metabolic functions that occur during
sleep are active areas of research. Prior studies have focused on sugars and nucleotides …

Flickering light stimulation has emerged as a promising non-invasive neuromodulation
strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical …

Sleep is regulated by homeostatic processes, yet the biological basis of sleep pressure that
accumulates during wakefulness, triggers sleep, and dissipates during sleep remains …

Progress has been made in the elucidation of sleep and wakefulness regulation at the
neurocircuit level,. However, the intracellular signalling pathways that regulate sleep and the …

Mammals exhibit circadian cycles of sleep and wakefulness under the control of the
suprachiasmatic nucleus (SCN), such as the strong arousal phase-locked to the beginning …

Sleep need accumulates during waking and dissipates during sleep to maintain sleep
homeostasis (process S). Besides the regulation of daily (baseline) sleep amount …

Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep for
its revitalizing function, but the mechanism underlying sleep homeostasis remains poorly …

The phosphorylation of synaptic proteins is a significant biochemical reaction that controls
the sleep–wake cycle in mammals,–. Protein phosphorylation in vivo is reversibly regulated …