The vaginal microbiome in health and disease—what role do common intimate hygiene practices play?

AM Holdcroft, DJ Ireland, MS Payne - Microorganisms, 2023 - mdpi.com
The vaginal microbiome is a dynamic, sensitive microenvironment. The hallmark of a
'healthy'vaginal microbiome is currently believed to be one dominated by Lactobacillus spp …

The vaginal microbiota, host defence and reproductive physiology

SB Smith, J Ravel - The Journal of physiology, 2017 - Wiley Online Library
The interaction between the human host and the vaginal microbiota is highly dynamic. Major
changes in the vaginal physiology and microbiota over a woman's lifetime are largely …

VALENCIA: a nearest centroid classification method for vaginal microbial communities based on composition

MT France, B Ma, P Gajer, S Brown, MS Humphrys… - Microbiome, 2020 - Springer
Background Taxonomic profiles of vaginal microbial communities can be sorted into a
discrete number of categories termed community state types (CSTs). This approach is …

Temporal and spatial variation of the human microbiota during pregnancy

DB DiGiulio, BJ Callahan, PJ McMurdie… - Proceedings of the …, 2015 - pnas.org
Despite the critical role of the human microbiota in health, our understanding of microbiota
compositional dynamics during and after pregnancy is incomplete. We conducted a case …

Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis

N Brusselaers, S Shrestha, J Van De Wijgert… - American journal of …, 2019 - Elsevier
Objective The vaginal microbiota proposedly influence the association between human
papillomavirus and cervical cancer. Our aim was to assess whether vaginal dysbiosis affects …

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

R Romero, SS Hassan, P Gajer, AL Tarca, DW Fadrosh… - Microbiome, 2014 - Springer
Background This study was undertaken to characterize the vaginal microbiota throughout
normal human pregnancy using sequence-based techniques. We compared the vaginal …

Bacterial vaginosis: current diagnostic avenues and future opportunities

MJ Redelinghuys, J Geldenhuys, H Jung… - Frontiers in cellular and …, 2020 - frontiersin.org
A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen
peroxide producing bacteria, which provide protection against infections by maintaining a …

Temporal dynamics of the human vaginal microbiota

P Gajer, RM Brotman, G Bai, J Sakamoto… - Science translational …, 2012 - science.org
Elucidating the factors that im**e on the stability of bacterial communities in the vagina
may help in predicting the risk of diseases that affect women's health. Here, we describe the …

The application of ecological theory toward an understanding of the human microbiome

EK Costello, K Stagaman, L Dethlefsen… - Science, 2012 - science.org
The human-microbial ecosystem plays a variety of important roles in human health and
disease. Each person can be viewed as an island-like “patch” of habitat occupied by …

Integrating compositional and functional content to describe vaginal microbiomes in health and disease

JB Holm, MT France, P Gajer, B Ma, RM Brotman… - Microbiome, 2023 - Springer
Background A Lactobacillus-dominated vaginal microbiome provides the first line of defense
against adverse genital tract health outcomes. However, there is limited understanding of …