Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Among the ten subtypes of mammalian voltage-gated calcium (Ca v) channels, Ca v 3.1–Ca
v 3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

The Cav3. 2 subtype of T-type calcium channels has been targeted for develo**
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …

T-type calcium channels regulate neuronal excitability and are important contributors of pain
processing. CaV3. 2 channels are the major isoform expressed in nonpeptidergic and …

T-type calcium channels serve an essential role in the functioning of the nervous system.
They exhibit unique properties among voltage-gated calcium channels, and mediate specific …

Cav3. 2 T‐type calcium channels are important regulators of pain signals in the afferent pain
pathway, and their activities are dysregulated during various chronic pain states. Therefore …