Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

V Batarchuk, Y Shepelytskyi, V Grynko… - International Journal of …, 2024 - mdpi.com
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …

Recent Applications of Pillar[n]arene-Based Host–Guest Recognition in Chemosensing and Imaging

Y Li, J Wen, J Li, Z Wu, W Li, K Yang - ACS sensors, 2021 - ACS Publications
Pillar [n] arene is a novel kind of synthetic supramolecular macrocyclic host characterized by
its particular pillar-shaped structure consisting of an electron-rich cavity and two finely …

Structural and functional imaging of brains

Z Liu, Y Zhu, L Zhang, W Jiang, Y Liu, Q Tang… - Science China …, 2023 - Springer
Analyzing the complex structures and functions of brain is the key issue to understanding the
physiological and pathological processes. Although neuronal morphology and local …

Chiral pillar [5] arene-functionalized silica microspheres: synthesis, characterization and enantiomer separation

C Shi, H Li, X Shi, L Zhao, H Qiu - Chemical Communications, 2022 - pubs.rsc.org
Chiral pillar [5] arene-functionalized silica microspheres were prepared and characterized
for the first time, and can be used as a new kind of chiral stationary phase for effective …

R3-Noria-Methanesulfonate: A Molecular Cage with Superior Hyperpolarized Xenon-129 MRI Contrast

Y Shepelytskyi, V Grynko, V Batarchuk… - ACS …, 2023 - ACS Publications
Hyperpolarized (HP) xenon-129 (129Xe) magnetic resonance imaging (MRI) has the
potential to be used as a molecular imaging modality. For this purpose, numerous …

Cyclic and acyclic acetals as safe, nonaqueous formaldehyde equivalents for the synthesis of pillararenes

B Machireddy, M He - Chemical Communications, 2024 - pubs.rsc.org
Pillar [5] arene was synthesized using acyclic acetals diethoxymethane and
dimethoxymethane, and cyclic acetals 1, 3-dioxolane and 1, 3, 5-trioxane as an alternative …

Cucurbit [6] uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0 T

V Grynko, Y Shepelytskyi, V Batarchuk… - …, 2023 - Wiley Online Library
Molecular imaging is the future of personalized medicine; however, it requires effective
contrast agents. Hyperpolarized chemical exchange saturation transfer (HyperCEST) can …

Ultrasensitive 129Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing

Y Yang, S Yue, L Shen, H Dong, H Li, X Zhao… - Advanced …, 2025 - Wiley Online Library
Magnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in
vivo research, offering unparalleled visualization capabilities. Despite significant …

Pillar [n] arene‐Based Supramolecular Nanodrug Delivery Systems for Cancer Therapy

S Wei, X Cui, T Li, X Ma, L Liu - ChemMedChem, 2025 - Wiley Online Library
Macrocyclic supramolecular materials play an important role in encapsulating anticancer
drugs to improve the anticancer efficiency and reduce the toxicity to normal tissues through …

Magnetic resonance detection of gas microbubbles via hypercest: A path toward dual modality contrast agent

CT McHugh, PG Durham, M Kelley, PA Dayton… - …, 2021 - Wiley Online Library
Gas microbubbles are an established clinical ultrasound contrast agent. They could also
become a powerful magnetic resonance (MR) intravascular contrast agent, but their low …