Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …

Selective autophagy regulates the abundance of specific cellular components via a
specialized arsenal of factors, termed autophagy receptors, that target protein complexes …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Abstract Alpha-synuclein (α-syn) is central to the pathogenesis of Parkinson disease (PD).
Gene duplications, triplications and point mutations in SNCA1, the gene encoding α-syn …

Fibrillar aggregates of the α-synuclein (αS) protein are the hallmark of Parkinson's Disease
and related neurodegenerative disorders. Characterization of the effects of mutations and …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …

α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …

Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …