Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Bile acids are physiological detergents that generate bile flow and facilitate intestinal
absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling …

Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the
rate-limiting step in bile acid biosynthesis. Although bile acids activate the farnesoid X …

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild …

The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In
addition to this metabolic function, bile acids also act as signaling molecules that negatively …

The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and
subsequent gene targeting studies in mice provided strong evidence that LXR plays a …

The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that
are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate …