Development of new local anesthetic agents has been focused on the potency of their nerve‐
blocking effects, duration of action and safety and has resulted in a substantial number of …

Clinical and basic science studies have demonstrated the anti‐inflammatory properties of
local anaesthetics. Recent studies have begun to unravel molecular pathways linking …

Background The metastatic potential of breast cancer cells has been strongly associated
with overexpression of the chemokine CXCL12 and the activity of its receptor CXCR4 …

Background Natural killer (NK) cells can induce death in cancer cells. Previous studies
suggest that lidocaine may decrease the function of NK cells. However, it is unknown …

Background context Analgesic effect of lidocaine infusion on postoperative pain. Purpose
The aim of this study was to evaluate the analgesic effect of lidocaine infusion on …

Background Adipose stem cells have gained great interest in plastic and reconstructive
surgery with their ability to improve engraftment after fat transfer for soft tissue filling. It is …

Background Mortality from sepsis frequently results from multiple organ injury and
dysfunction. Cecal ligation and puncture is an established murine model of septic peritonitis …

Background Perioperative myocardial ischemia poses a vital threat to surgical patients.
Means to protect postischemic myocardium are clinically not available. Lidocaine has been …

BACKGROUND: Lidocaine is used clinically for tactile allodynia associated with diabetes-
induced neuropathy. Although the analgesic effect of lidocaine through suppression of …

The present study was designed to determine the renoprotective and hepatoprotective effect
of lidocaine in septic rats through the Toll-like receptor 4 (TLR4) signaling pathway. Adult …