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Thiophene-based derivatives as anticancer agents: An overview on decade's work
Heterocyclic compounds hold a pivotal place in medicinal chemistry due to their wide range
of biological activities and thus, are exhaustively explored in the field of drug design and …
of biological activities and thus, are exhaustively explored in the field of drug design and …
Therapeutic potential of oxadiazole or furadiazole containing compounds
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …
Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity
Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure …
Abstract SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19
caused a severe health threat throughout the world. Lack of specific treatments raised an …
caused a severe health threat throughout the world. Lack of specific treatments raised an …
Synthesis, antiproliferative and apoptosis induction potential activities of novel bis (indolyl) hydrazide-hydrazone derivatives
In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …
inhibition and apoptosis induction characteristics are being strongly screened for their …
[HTML][HTML] Synthesis, molecular docking study, and cytotoxic activity against MCF cells of new Thiazole–Thiophene scaffolds
Investigating novel compounds that may be useful in designing new, less toxic, selective,
and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus …
and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus …
Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents
A novel library of chalcone linked thiazole-imidazopyridine (12a–j) derivatives were
designed, synthesized, and their structures were characterized by 1 H NMR, 13 C NMR and …
designed, synthesized, and their structures were characterized by 1 H NMR, 13 C NMR and …
Design, synthesis, and biological evaluation of 1, 2, 4-thiadiazole-1, 2, 4-triazole derivatives bearing amide functionality as anticancer agents
YJ Pragathi, R Sreenivasulu, D Veronica… - Arabian journal for …, 2021 - Springer
A novel library of amide functionality having 1, 2, 4-thiadiazole-1, 2, 4-triazole (8a–j) analogs
was designed, synthesized, and structures were characterized by 1 H NMR, 13 C NMR, and …
was designed, synthesized, and structures were characterized by 1 H NMR, 13 C NMR, and …
Synthesis, anticancer evaluation and molecular docking studies of 2, 5-bis (indolyl)-1, 3, 4-oxadiazoles, Nortopsentin analogues
A series of ten novel 2, 5-bis (indolyl)-1, 3, 4-oxadiazoles were designed and synthesized.
All these compounds were evaluated for their cytotoxicity against four cancer cell lines …
All these compounds were evaluated for their cytotoxicity against four cancer cell lines …