RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
F Xu, L Na, Y Li, L Chen - Cell & bioscience, 2020 - Springer
Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …
signal transduction and biological processes such as cell proliferation, apoptosis …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
GSK3 and its interactions with the PI3K/AKT/mTOR signalling network
Abstract Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and
its phosphorylation of its diverse substrates has major influences on many areas of …
its phosphorylation of its diverse substrates has major influences on many areas of …
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …
investigation of coordination and organometallic complexes of alternative metal centers for …
Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …
recognized a promising drug discovery target in treating multiple pathological conditions …
Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: outlook beyond TSPO
V Narayanaswami, K Dahl… - Molecular …, 2018 - journals.sagepub.com
The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …
The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …
of people around the world, characterized by a complex and age-related progressive …
Targeting glycogen synthase kinase-3β for Alzheimer's disease: recent advances and future Prospects
Z Cheng, T Han, J Yao, K Wang, X Dong, F Yu… - European Journal of …, 2024 - Elsevier
Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
Kinases as potential therapeutic targets for anti-coronaviral therapy
The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …