Cells, grown as monolayers (2D models), are routinely used as initial model systems for
evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic …

There is a growing demand for three-dimensional scaffolds for expanding applications in
regenerative medicine, tissue engineering, and cell culture techniques. The material …

The behaviour of cells cultured within three-dimensional (3D) structures rather than onto two-
dimensional (2D) culture plastic more closely reflects their in vivo responses. Consequently …

Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …

The implementation of microfluidic devices within life sciences has furthered the possibilities
of both academic and industrial applications such as rapid genome sequencing, predictive …

The development of safe, effective and patient-acceptable drug products is an expensive
and lengthy process and the risk of failure at different stages of the development life-cycle is …

Purpose of this study was the development of a 3D material to be used as substrate for
breast cancer cell culture. We developed composite gels constituted by different …

Cells cultured within a three-dimensional (3D) in vitro environment have the ability to
acquire phenotypes and respond to stimuli analogous to in vivo biological systems. This …

Tumor-targeted drug delivery systems are promising for their advantages in enhanced tumor
accumulation and reduced toxicity towards normal organs. However, few nanomedicines …

Engineering synthetic hydrogels on a molecular basis to introduce natural features that are
important in instructing cell behavior is becoming increasingly crucial in biomaterial-based …