Mortality from colorectal cancer is reduced through screening and early detection; moreover,
removal of neoplastic lesions can reduce cancer incidence. While understanding of the risk …

The strongest nonmodifiable risk factors for CRC and precancerous polyps are age, male
sex, and family history of CRC. Current evidence indicates that smoking, obesity, and diet …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Background & Aims Endoscopic screening reduces incidence and mortality of colorectal
cancer (CRC) because precursor lesions, such as conventional adenomas or serrated …

Objective Colorectal cancer (CRC) screening has been widely implemented in many
countries. However, evidence on participation and diagnostic yield of population-based …

Background The role of poor diet quality in the rising incidence of colorectal cancer (CRC)
diagnosed younger than age 50 years has not been explored. Based on molecular features …

Background & Aims Vitamin D has been implicated in colorectal cancer (CRC)
pathogenesis, but it remains unknown whether total vitamin D intake is associated with early …

High-fat diet, which leads to an increased level of deoxycholic acid (DCA) in the intestine, is
a major environmental factor in the development of colorectal cancer (CRC). However …

Background Growing evidence indicates the adverse effect of ultra-processed food (UPF)
consumption. However, it remains unknown whether UPF consumption influences the risk of …

Background Smoking and alcohol increase risk for colorectal malignancies. However,
colorectal cancer (CRC) is a heterogenic disease and associations with the molecular …