Molecular nature and physiological role of the mitochondrial calcium uniporter channel
BR Alevriadou, A Patel, M Noble… - … of Physiology-Cell …, 2021 - journals.physiology.org
Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …
[HTML][HTML] MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology
J Wang, J Jiang, H Hu, L Chen - Journal of Advanced Research, 2024 - Elsevier
Background Globally, the onset and progression of multiple human diseases are associated
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …
[HTML][HTML] From passage to inhibition: Uncovering the structural and physiological inhibitory mechanisms of MCUb in mitochondrial calcium regulation
DM Colussi, PB Stathopulos - The FASEB Journal, 2023 - ncbi.nlm.nih.gov
Abstract Mitochondrial calcium (Ca 2+) regulation is critically implicated in the regulation of
bioenergetics and cell fate. Ca 2+, a universal signaling ion, passively diffuses into the …
bioenergetics and cell fate. Ca 2+, a universal signaling ion, passively diffuses into the …
[HTML][HTML] The MCU and MCUb amino-terminal domains tightly interact: mechanisms for low conductance assembly of the mitochondrial calcium uniporter complex
Summary The mitochondrial calcium (Ca 2+) uniporter (MCU) complex is regulated via
integration of the MCU dominant negative beta subunit (MCUb), a low conductance paralog …
integration of the MCU dominant negative beta subunit (MCUb), a low conductance paralog …
[HTML][HTML] Structural basis of Ca2+ uptake by mitochondrial calcium uniporter in mitochondria: a brief review
J Yoo - BMB reports, 2022 - ncbi.nlm.nih.gov
Mitochondria are cellular organelles that perform various functions within cells. They are
responsible for ATP production, cell-signal regulation, autophagy, and cell apoptosis …
responsible for ATP production, cell-signal regulation, autophagy, and cell apoptosis …
Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation
W Wu, J Zheng, Z Jia - Iscience, 2021 - cell.com
The mitochondrial uniporter is a Ca 2+-selective ion-conducting channel in the inner
mitochondrial membrane that is involved in various cellular processes. The components of …
mitochondrial membrane that is involved in various cellular processes. The components of …
Structural mechanisms of store-operated and mitochondrial calcium regulation: initiation points for drug discovery
M Noble, QT Lin, C Sirko, JA Houpt, MJ Novello… - International Journal of …, 2020 - mdpi.com
Calcium (Ca2+) is a universal signaling ion that is essential for the life and death processes
of all eukaryotes. In humans, numerous cell stimulation pathways lead to the mobilization of …
of all eukaryotes. In humans, numerous cell stimulation pathways lead to the mobilization of …