The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions
3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
Oxidative stress basically defines a condition in which prooxidant–antioxidant balance in the
cell is disturbed; cellular biomolecules undergo severe oxidative damage, ultimately …
cell is disturbed; cellular biomolecules undergo severe oxidative damage, ultimately …
Reactive oxygen species, cellular redox systems, and apoptosis
ML Circu, TY Aw - Free radical biology and medicine, 2010 - Elsevier
Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic
exposure, and depending on their concentration, ROS can be beneficial or harmful to cells …
exposure, and depending on their concentration, ROS can be beneficial or harmful to cells …
Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm
Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …
diversity of cellular processes during development but also plays a pivotal role in …
Mechanisms of cell death in oxidative stress
SW Ryter, HP Kim, A Hoetzel, JW Park… - Antioxidants & redox …, 2007 - liebertpub.com
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …
environmental stress have long been implicated in tissue injury in the context of a variety of …
14-3-3 proteins: structure, function, and regulation
H Fu, RR Subramanian… - Annual review of …, 2000 - annualreviews.org
The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …
Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance
The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
A review of the mammalian unfolded protein response
Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
AH Kim, GUS Khursigara, X Sun… - … and cellular biology, 2001 - Taylor & Francis
The Akt family of serine/threonine-directed kinases promotes cellular survival in part by
phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional …
phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional …
Structural basis of 14-3-3 protein functions
T Obsil, V Obsilova - Seminars in cell & developmental biology, 2011 - Elsevier
The 14-3-3 proteins, a family of conserved regulatory molecules, participate in a wide range
of cellular processes through binding interactions with hundreds of structurally and …
of cellular processes through binding interactions with hundreds of structurally and …