The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
Lessons for COVID-19 immunity from other coronavirus infections
A Sariol, S Perlman - Immunity, 2020 - cell.com
A key goal to controlling coronavirus disease 2019 (COVID-19) is develo** an effective
vaccine. Development of a vaccine requires knowledge of what constitutes a protective …
vaccine. Development of a vaccine requires knowledge of what constitutes a protective …
Activation and evasion of type I interferon responses by SARS-CoV-2
X Lei, X Dong, R Ma, W Wang, X **ao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some
cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus …
cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus …
[HTML][HTML] MDA5 governs the innate immune response to SARS-CoV-2 in lung epithelial cells
Recent studies have profiled the innate immune signatures in patients infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular …
[HTML][HTML] The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier
As researchers across the globe have focused their attention on understanding SARS-CoV-
2, the picture that is emerging is that of a virus that has serious effects on the vasculature in …
2, the picture that is emerging is that of a virus that has serious effects on the vasculature in …
Comparison of virus concentration methods for the RT-qPCR-based recovery of murine hepatitis virus, a surrogate for SARS-CoV-2 from untreated wastewater
There is currently a clear benefit for many countries to utilize wastewater-based
epidemiology (WBE) as part of ongoing measures to manage the coronavirus disease 2019 …
epidemiology (WBE) as part of ongoing measures to manage the coronavirus disease 2019 …
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …