In the past decade, the term organoid has moved from obscurity to common use to describe
a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of …

Kidney disease is a global health crisis affecting more than 850 million people worldwide. In
the United States, annual Medicare expenditures for kidney disease and organ failure …

Podocytes form the backbone of the glomerular filtration barrier and are exposed to various
mechanical forces throughout the lifetime of an individual. The highly dynamic …

Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

Heterozygosity for inverted formin-2 (INF2) mutations causes focal segmental
glomerulosclerosis (FSGS) with or without Charcot-Marie-Tooth disease. A key question is …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Background The proximal tubule plays a major role in electrolyte homeostasis. Previous
studies have shown that HNF4A regulates reabsorption-related genes and promotes …

Over the past decade, the induction protocols for the two types of kidney organoids (nephron
organoids and ureteric bud organoids) from pluripotent stem cells (PSCs) have been …

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Develo** disease models and screening for effective drugs are key areas of modern
medical research. Traditional methodologies frequently fall short in precisely replicating the …