Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcoma (OS), chondrosarcoma, and chordoma are characterized by multiple
challenges to the investigator, clinician, and patient. One consequence of their rarity among …

Primary bone tumours are rare, accounting for< 0.2% of malignant neoplasms registered in
the EUROCARE (European Cancer Registry based study on survival and care of cancer …

Introduction: In the early seventies chemotherapy significantly improved survival in
osteosarcoma. Since then minor innovations have occurred although recent years have …

Highlights•Although rare, bone cancers frequently cause death in the pediatric population.•
Osteosarcoma patient survival has plateaued over the last 20 years.•The large tumor …

Background Osteosarcoma (OS) is the most common primary malignant bone tumor.
Compared with previous treatment modalities, such as amputation, more recent …

This manuscript describes the experience from registration until randomisation for a cohort
of 2260 patients with osteosarcoma who joined the EURAMOS-1 trial. This includes pre …

Osteosarcoma is a disease with many complex genetic abnormalities but few well defined
genetic drivers of tumor initiation and evolution. The disease is diagnosed and defined …

Background and aims The aim of this systematic review is to describe the epidemiology of
chordoma and to provide a clear overview of clinical prognostic factors predicting …

Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the
second most frequent malignant bone tumor. Due to its resistance to chemo-and …