Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined
cancers with different genetic drivers, clinical courses, and therapeutic responses. The …

An important challenge in the real-world management of patients with advanced clear-cell
renal cell carcinoma (aRCC) is determining who might benefit from immune checkpoint …

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal
cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Background Immune infiltration of breast tumours is associated with clinical outcome.
However, past work has not accounted for the diversity of functionally distinct cell types that …

Importance The presence of tumor-infiltrating lymphocytes (TILs) is a favorable prognostic
factor in breast cancer, and TILs may synergize with chemotherapy and immune checkpoint …

Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic
and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC …