Reverse vaccinology: develo** vaccines in the era of genomics
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
Adaptive immune responses in acute and chronic hepatitis C virus infection
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …
cause of human illness and death globally. Recent studies have yielded important insights …
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
P Kiepiela, K Ngumbela, C Thobakgale, D Ramduth… - Nature medicine, 2007 - nature.com
Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely
empirical. To define the relationship, at the population level, between the specificity of the …
empirical. To define the relationship, at the population level, between the specificity of the …
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
Identification of the transmitted/founder virus makes possible, for the first time, a genome-
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …
Specific memory within innate immune systems
J Kurtz - Trends in immunology, 2005 - cell.com
Research into immune defense has been considerably enriched by the increasing focus on
innate immunity. This type of immunity is still considered to lack specific memory, largely …
innate immunity. This type of immunity is still considered to lack specific memory, largely …
Impact of MHC class I diversity on immune control of immunodeficiency virus replication
PJR Goulder, DI Watkins - Nature Reviews Immunology, 2008 - nature.com
The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the
urgent need to refocus on the question of which T-cell responses are required to control HIV …
urgent need to refocus on the question of which T-cell responses are required to control HIV …
Population genomics of intrapatient HIV-1 evolution
F Zanini, J Brodin, L Thebo, C Lanz, G Bratt, J Albert… - Elife, 2015 - elifesciences.org
Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
HIV and SIV CTL escape: implications for vaccine design
PJR Goulder, DI Watkins - Nature Reviews Immunology, 2004 - nature.com
Cytotoxic T lymphocytes (CTLs) have a central role in the successful control of
immunodeficiency virus infection. Evasion of this immune response through CTL escape is …
immunodeficiency virus infection. Evasion of this immune response through CTL escape is …
[HTML][HTML] Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design
A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic
grip** sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
grip** sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte
(CTL) recognition is a major challenge for vaccine design. However, recent studies suggest …
(CTL) recognition is a major challenge for vaccine design. However, recent studies suggest …