Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
The neurovascular unit dysfunction in Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Y Yang, W Zhang, AG Murzin, M Schweighauser… - Acta …, 2023 - Springer
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in
amyloid-β (Aβ)], causes dominantly inherited Alzheimer's disease. Here, we report the high …
amyloid-β (Aβ)], causes dominantly inherited Alzheimer's disease. Here, we report the high …
Genetics of β-amyloid precursor protein in Alzheimer's disease
Alzheimer's disease (AD) is characterized neuropathologically by neuronal cell loss,
extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary …
extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary …
Clinical considerations in early-onset cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease
associated with brain haemorrhage and cognitive change. The commonest form, sporadic …
associated with brain haemorrhage and cognitive change. The commonest form, sporadic …
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease
Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
S Weggen, D Beher - Alzheimer's research & therapy, 2012 - Springer
Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes
cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early …
cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early …
Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer's disease
MOW Grimm, J Mett, CP Stahlmann… - Frontiers in aging …, 2013 - frontiersin.org
One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …
Canine cognitive dysfunction and Alzheimer's disease–two facets of the same disease?
S Prpar Mihevc, G Majdič - Frontiers in neuroscience, 2019 - frontiersin.org
Neurodegenerative diseases present a major and increasing burden in the societies
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …
Understanding the pathophysiology of cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease,
is a major cause of spontaneous intracerebral haemorrhage and an important contributor to …
is a major cause of spontaneous intracerebral haemorrhage and an important contributor to …