DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to
start leading-strand synthesis and every few hundred nucleotides during discontinuous …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

The human replisome is an elaborate arrangement of molecular machines responsible for
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated
to promote precise genome duplication in every cell cycle. To accomplish this, initiation is …

This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …

The eukaryotic replisome, organized around the Cdc45-MCM-GINS (CMG) helicase,
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …