Sex differences are increasingly recognized in the diagnosis and treatment of diseases.
Biologically, the primary distinction between females and males is rooted in their sex …

Abstract Acute Myeloid Leukaemia (AML) is characterized by uncontrolled growth of
immature myeloid cells, disrupting normal blood production. Treatment typically involves …

The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-
based differences in precision oncology. Over 50% of clinically actionable oncology genes …

Given the heterogeneity of acute myeloid leukemia patients, it is necessary to identify
patients considered fit for intensive therapy but who will perform poorly, and in whom …

Current therapies for high-grade TP53-mutated myeloid neoplasms (≥ 10% blasts) do not
offer a meaningful survival benefit except allogeneic stem cell transplantation in the minority …

Core‐binding factor acute myeloid leukemia (CBF‐AML) is characterized by the presence of
inv (16)/t (16; 16) or t (8; 21) and is classified as a favorable risk by the 2022 European …

Acute myeloid leukemia (AML) with t (9; 22)(q34. 1; q11. 2)/BCR:: ABL1, a distinct entity
within the group of AML with defining genetic abnormalities, belong to the adverse-risk …

Gene expression varies stochastically across genders, racial groups, and health statuses.
Deciphering these patterns is crucial for identifying informative genes, classifying samples …

Clonal hematopoiesis (CH) refers to expanded clones of hematopoietic stem cell
progenitors, which harbor a genetic mutation, contributing to hematopoiesis, and …

Sex affects cancer genomes | Nature Reviews Cancer Skip to main content Thank you for
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