The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

Many drugs fail in the clinical trials and therefore do not reach the market due to adverse
effects on cardiac electrical function. This represents a growing concern for both regulatory …

Human ether‐á‐go‐go related gene (hERG) potassium (K+) channels play a critical role in
cardiac action potential repolarization. This is due, in large part, to the unique gating …

Ion channels are intimately involved in the everyday physiological functions that enable us
to live a full and varied life. When disease strikes, malfunction of ion channels or their …

Highlights•hERG1 potassium channels mediate repolarization of cardiac action
potentials.•hERG1 agonists alter channel gating to shorten action potential duration and QT …

Abstract Long‐QT syndrome type‐2 (LQT2) is characterized by reduced functional
expression of the human ether‐à‐go‐go related (hERG) gene product, resulting in impaired …

Human ether-a-go-go related gene (hERG) potassium (K+) channels play a critical role in
cardiac action potential repolarization. Mutations that reduce hERG conductance or surface …

Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of
cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to …